I would say the best way to avoid spam is by adopting a GMail account. Their antispam algorithm is second to none. I use GMail for like 6 years now and I believe I have received like 3 spam messages so far. What happens is they filter spam mail away. Still if some spam somehow manages to go through, you can mark it as spam so it learns to mark it as spam next time.
Even safer would be to browse gmail online instead of downloading e-mails.